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Structured Review

ComboSyn Inc compusyn software
Compusyn Software, supplied by ComboSyn Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/compusyn+software/compusyn+software/pmc12269308-174-7-9
Average 90 stars, based on 1 article reviews
compusyn software - by Bioz Stars, 2026-09
90/100 stars

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Concentration Assay:

Article Title: Unveiling Synergistic Antioxidant Effects of Green Tea and Peppermint: Role of Polyphenol Interactions and Blend Preparation.
Article Snippet: .. Both the CI and DRI, along with the concentration required for 50% inhibition (IC50), were calculated using median-effect analysis via CompuSyn software version 1.0.1. (ComboSyn, Inc., Paramus, NJ, USA). ..

Inhibition:

Article Title: Unveiling Synergistic Antioxidant Effects of Green Tea and Peppermint: Role of Polyphenol Interactions and Blend Preparation.
Article Snippet: .. Both the CI and DRI, along with the concentration required for 50% inhibition (IC50), were calculated using median-effect analysis via CompuSyn software version 1.0.1. (ComboSyn, Inc., Paramus, NJ, USA). ..

Software:

Article Title: Unveiling Synergistic Antioxidant Effects of Green Tea and Peppermint: Role of Polyphenol Interactions and Blend Preparation.
Article Snippet: .. Both the CI and DRI, along with the concentration required for 50% inhibition (IC50), were calculated using median-effect analysis via CompuSyn software version 1.0.1. (ComboSyn, Inc., Paramus, NJ, USA). ..

Article Title: Martinostat as a novel HDAC inhibitor to overcome tyrosine kinase inhibitor resistance in chronic myeloid leukemia
Article Snippet: The samples were analyzed using a FACSCalibur flow cytometer (BD Biosciences), and the data were processed using the FlowJo software (version 10.4.1; Treestar, Ashland, OR, USA). .. The combination index (CI) was calculated using CompuSyn software (ComboSyn Inc., Paramus, NJ, USA). .. The intracellular ATP content was determined using a CellTiter-Glo ® Luminescent Cell Viability Assay (Promega, Madison, WI, USA).

Article Title: EZH2 inhibitor SHR2554 enhances the anti-tumor efficacy of HDAC inhibitor Chidamide through STAT1 in T-cell lymphoma.
Article Snippet: ✉email: lxywumeng@foxmail.com; dingdingply1981@163.com; zhu-jun2017@outlook.com Edited by Dr Gemma Kelly www.nature.com/cddis Official journal of CDDpress 1 2 3 4 5 6 7 8 9 0;,: Cell viability was assessed using the CellTiter-Glo Luminescent Cell Viability Assay System (Promega, Madison, USA, #G7572). .. Synergistic effects were analyzed using CompuSyn software (ComboSyn Inc, NJ, USA) [20]. .. Cell apoptosis and cell cycle assays For the apoptosis assay, cells were resuspended in 1× Binding Buffer and stained with Annexin V-FITC and propidium iodide (PI) using an apoptosis detection kit (Dojindo Laboratories, Kumamoto, Japan, #AD10).

Article Title: Microvesicle inhibition enhances the therapeutic effects of ATRA in acute promyelocytic leukemia cells via changes in miRNAs: the promising antileukemic potential of imipramine.
Article Snippet: .. The interaction between imipramine and ATRA was estimated by calculating the combination index (CI) using CompuSyn Software (ComboSyn, Inc., Paramus, NJ, USA). ..

Article Title: An Experimental Rat Model for Simultaneous Induction of Peripheral Neuropathy and Myelotoxicity by Docetaxel Administration: Evaluating the Protective Role of Dimethyl Fumarate.
Article Snippet: .. The CompuSyn software (version 1.0; ComboSyn, Inc., Paramus, NJ, USA) was used to calculate the combination index (CIX), where CIX = 1 indicates an additive effect, CIX < 1 indicates synergy, and CIX > 1 indicates antagonism. ..

Article Title: A brain-penetrant CDK4/6 inhibitor - AU3-14 shows robust anti-tumor efficacy against glioblastoma.
Article Snippet: For combination studies, cells were treated with AU3–14, TMZ at 400 μM, or their combination for 144 h. Pre-treatment schedules involved sequential exposure to each compound for 72 h. Media and compounds were replaced every 72 h. After treatment, 50 μL of MTT solution (3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide; ThermoFisher Scientific, Victoria, Australia) was added and the absorbance was measured at 560 nm using a PerkinElmer plate reader (Buckinghamshire, UK). .. The effects of the combination treatments were analyzed using the Chou-Talalay method [36] through the CompuSyn software (ComboSyn, New Jersey, USA), where combination index (CI) values of < 1, 1, and > 1 were indicative of synergistic, additive, and antagonistic interactions, respectively. .. Half-maximal growth inhibitory concentrations (GI50) were determined using GraphPad Prism 10 (California, USA) employing a nonlinear regression model with a four-parameter logistic fit.

Article Title: EZH2 inhibitor SHR2554 enhances the anti-tumor efficacy of HDAC inhibitor Chidamide through STAT1 in T-cell lymphoma
Article Snippet: Cell viability was assessed using the CellTiter-Glo Luminescent Cell Viability Assay System (Promega, Madison, USA, #G7572). .. Synergistic effects were analyzed using CompuSyn software (ComboSyn Inc, NJ, USA) [ ]. .. For the apoptosis assay, cells were resuspended in 1× Binding Buffer and stained with Annexin V-FITC and propidium iodide (PI) using an apoptosis detection kit (Dojindo Laboratories, Kumamoto, Japan, #AD10).

Article Title: Assessing Auranofin for Second‐Line Use in Chemoresistant Ovarian Cancer: Effects on Tumour Spheroid and Primary Cell Growth
Article Snippet: .. CI was then calculated with the method developed by Chou and Talalay [ ], using CompuSyn software ( www.combosyn.com ). .. The evaluation of cell death was carried out using the TACS annexin V/propidium iodide staining kit (Trevigen, Gaithersburg, MD, USA) according to the manufacturer's instructions.



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